2. Anxiety
General Anxiety Disorder & Post Traumatic Stress Disorder
General Anxiety Disorder
Anxiety is a problem that a lot of people have. It can happen because of many different things, like your genes, how your brain works, what you eat, and things that happen in your life. Anxiety makes you feel really worried and scared, even if there isn't anything really wrong. Doctors usually give medication to help with anxiety, but sometimes it doesn't work for everyone. Anxiety is your brain's way of reacting to things that it thinks are scary or dangerous. Sometimes it's normal to feel a little bit anxious, but when it gets really bad and you can't control it, that's called Generalized Anxiety Disorder.
Benefits of IV Infusions
Three systematic reviews suggest that short infusions of a safe anaesthetic drug, at sub-anaesthethic doses, may have potential in treating refractory anxiety disorders. There is growing evidence supporting the use of it in anxiety disorders due to its unique mechanism of action, rapid onset, and high response rate. This infusion may have broad effectiveness across treatment-resistant anxiety spectrum disorders, with a dose response profile observed for it and changes in social anxiety disorder symptoms. One review highlights the temporary nature of the anxiolytic effects of this infusion and discuss the possible involvement of n-Methyl d-Aspartate (NMDA) receptor antagonism and other receptors in anxiety reduction. Further research is needed to determine the long-term safety and tolerability of it and its effectiveness in treating anxiety disorders.
Post Traumatic Stress Disorder (PTSD)
PTSD is a mental illness that can happen to people who have experienced really scary or dangerous things, like war or a bad accident. It makes you feel really bad and can last for a long time. Lots of people can get PTSD, not just soldiers and emergency workers. If you don't get help for it, you might have bad memories, avoid things that remind you of the trauma, and have trouble being happy or talking to people. Sometimes, people with PTSD also feel really sad, scared, and might even think about hurting themselves. Doctors might give you medication to help with PTSD, but it doesn't always work well and can be addictive. So, some people might use drugs or alcohol to try and feel better, but that's not a good idea either.
Benefits of IV Infusions
This infusion has shown potential as a treatment option for PTSD, which has limited effective pharmacological agents and trauma-focused psychotherapies available. A recent systematic review reviewed clinical evidence of it in treating PTSD and found encouraging signals of therapeutic safety, efficacy, and durability from case reports, chart reviews, open-label studies, and randomized trials. A randomized controlled trial found that repeated administration of this infusion significantly reduced symptom severity in individuals with chronic PTSD compared to midazolam. 67% of participants in the test group responded to treatment, and the median time to benefit was 27.5 days following the 2-week course of infusions. Further studies are needed to fully understand the potential of this infusion as a treatment for chronic PTSD.
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